Top 5 Lab on a Chip Company

Hidden costs of PDMS

Skyphos offers cost-effective solutions for microfluidic device development, reducing expenses associated with traditional fabrication methods. Learn how our advanced 3D printing platform can save you time and resources in diagnostics and biotechnology

What does a chip cost?

On average, it is assumed that a PDMS chip costs about $1, but is this the true cost? $1 doesn't include mask and master charges,  wait time, overhead for keeping the lights on at the lab, technician time, specialized chemicals and dedicated lab space to perform SU-8 or clean-room time.  It certainly doesn't account for these time losses compounded over several development phases to get to publication or trials.  It doesn't account for mistakes of positive/negative masks, or the difficulty and failure rates assembling multi-layer chip.

The true cost is closer to $120-$200 per device.

Below is a comparison between Skyphos, in-house, and a PDMS service. You need a manufacturing process that is developed from the ground up to support the product throughout it’s lifecycle - from prototype to production it needs to be proven.


Time is money - grant money, first to market money…It takes time to create PDMS devices, masks and molds, even in the lab hours spent at low success rates for devices. This time adds up, you have to keep the lights on, the employees paid, machines in working order. Skyphos offers the lowest downtime of any service. So what about if you already have the molds and are just making replicas?

3D printing for Lab on a Chip and microfluidics Costs

Prototype | Production | Proven


Skyphos is faster and cheaper for 3d printing microdevices

In the case of making devices from molds already available, the win is getting devices faster. The trade-off is that these devices will be constructed from PDMS. When moving towards a launch or possible IP strategy, Skyphos offers and advantage in that the devices being tested will be exactly the same as the final product. Moving to Skyphos earlier will allow faster results in the long run - ie the next design iteration.

*Note: PDMS Replica represents the situation where the lab already has a mold set ready for use. In the case where a new mold set needs to be created, Skyphos delivers a better value than using in-house labor. You do science, Skyphos does service.


Cost per chip made easy:


Skyphos makes it easy, and fast. Drop the 6 week lead-time and test your idea the same week. 

For an order quantity of 10 of multi-layer devices the ROI moves to Skyphos,

even if you have a set of molds ready and waiting in the lab.

At the outset, it appears PDMS in-house fabrication may be cheaper. However take a look at the length of time it takes to deliver product. Most of our customers find the sweet-spot to switch to Skyphos when they will be fabricating more than 10 chips in-house - even if they already have the molds.


“ You do science, Skyphos does service.”


Hidden costs of PDMS:

Time & Money

  • Each refinement costs on average: 6 weeks and $600 per layer

  • Each chip takes about 1-1.5 hours per layer to cure, assemble & port

  • Multi-layer designs add complexity, time, and failure opportunities

  • The process and applicable materials place limits on aspect ratios, (base to height is 1:2)

  • 2D extrusion-based designs limit surface area and signal-to-noise

  • Molds for hot embossing and hot injection can be as much as $80k per layer

  • Moving to hot-embossing or injection molding intoduces new materials often requiring further confirmation experiments

  • Progressing to final designs can cost 12 months in time, and $250,000+ in added costs


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Comparing Skyphos to hot embossing & injection molding


No question. Skyphos has the advantage when you want to go to market.